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| | WEHI-539 Basic information |
| Product Name: | WEHI-539 | | Synonyms: | WEHI-539;(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid;WEHI-539 ( CT-WE539);5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid;(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr;CS-1739;WEHI539;WEHI 539;4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]- | | CAS: | 1431866-33-9 | | MF: | C31H29N5O3S2 | | MW: | 583.72 | | EINECS: | | | Product Categories: | | | Mol File: | 1431866-33-9.mol |  |
| | WEHI-539 Chemical Properties |
| Boiling point | 827.6±75.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | 10.24±0.20(Predicted) |
| | WEHI-539 Usage And Synthesis |
| Uses | WEHI 539 is a selective BCL-XL inhibitor. | | Biological Activity | wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1]. | | target | BCL-XL | | references | [1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397. |
| | WEHI-539 Preparation Products And Raw materials |
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