| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:5'-O-Tritylinosine
CAS:4152-77-6
Package:100Mg,1g
|
|
| | 5’O-Tritylinosine Basic information |
| Product Name: | 5’O-Tritylinosine | | Synonyms: | 5’O-Tritylinosine;KIN-59;Inosine, 5'-O-(triphenylmethyl)-;5'-O-tritylinosine-2'-deoxyinosine;5'-O-Trt-rI | | CAS: | 4152-77-6 | | MF: | C29H26N4O5 | | MW: | 510.54 | | EINECS: | | | Product Categories: | | | Mol File: | 4152-77-6.mol |  |
| | 5’O-Tritylinosine Chemical Properties |
| solubility | DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL | | form | A crystalline solid |
| | 5’O-Tritylinosine Usage And Synthesis |
| Description | KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice. | | Uses | 5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. | | Uses | 5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. |
| | 5’O-Tritylinosine Preparation Products And Raw materials |
|