| Company Name: |
Matrix Scientific
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| Products Intro: |
Product Name:Hydroxydione sodium succinate
CAS:53-10-1
|
| Company Name: |
Aronis
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+79265780336 |
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aronis@aronis.ru |
| Products Intro: |
Product Name:Hydroxydione sodium succinate
CAS:53-10-1
Package:10g
|
HYDROXYDIONESODIUM manufacturers
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| | HYDROXYDIONESODIUM Basic information |
| Product Name: | HYDROXYDIONESODIUM | | Synonyms: | HYDROXYDIONESODIUM;HYDROXYDION;Presuren;Succinic acid 1-(sodium)4-(3,20-dioxo-5β-pregnan-21-yl) ester salt;Succinic acid 1-sodium 4-(3,20-dioxo-5β-pregnane-21-yl);Viadril;21-(3-Carboxy-1-oxopropoxy)-5-beta-pregnane-3,20-dione sodium salt;21-Hydroxy-5beta-pregnane-3,20-dione 21-(sodium succinate) | | CAS: | 53-10-1 | | MF: | C25H35NaO6 | | MW: | 454.54 | | EINECS: | | | Product Categories: | | | Mol File: | 53-10-1.mol |  |
| | HYDROXYDIONESODIUM Chemical Properties |
| | HYDROXYDIONESODIUM Usage And Synthesis |
| Originator | Viadril,Pfizer,US,1957 | | Manufacturing Process | A solution of 20 g of desoxycorticosterone in 190 ml of absolute ethanol was
stirred in an atmosphere of hydrogen in the presence of 1.68 g of 25%
palladium on calcium carbonate catalyst. After 20 hours, approximately 1
molar equivalent of hydrogen had been absorbed and hydrogen uptake had
ceased. The catalyst was removed by filtration and the filtrate evaporated in
vacuo to yield 20 g of nearly pure product, MP 135°C to 140°C. The crude
product was demonstrated to be free of starting material by paper
chromatography. A highly purified product was obtained by recrystallization
from acetone-water with cooling in an ice bath, yield 14.5 g, MP 152°C to
154°C. The product was characterized by analysis and by absence of
ultraviolet absorption.
A solution of 14 g of 21-hydroxypregnane-3,20-dione and of 14 g of
recrystallized succinic anhydride in 140 ml of dry pyridine was allowed to
stand at room temperature for 18 hours, then cooled in an ice bath and
poured in a fine stream into 1.5 liters of ice water. Excess pyridine was
neutralized with 3N hydrochloric acid and the solution further diluted with 2
liters of ice water. The precipitated product was filtered, washed with water
and dried in vacuo at 50°C affording 18 g of solid MP 192°C to 195°C.
Recrystallization of a small sample afforded analytically pure material, MP
200°C. | | Therapeutic Function | Anesthetic |
| | HYDROXYDIONESODIUM Preparation Products And Raw materials |
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