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| | Sofosbuvir IMpurity C Basic information |
| Product Name: | Sofosbuvir IMpurity C | | Synonyms: | Sofosbuvir IMpurity C 1337482-15-1;Ofosbuvi rimpurity;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate;Sofosbuvir impurity G;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph;L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-3'-uridylyl]-, 1-methylethyl ester;Sofosbuvir impurity 18/Sofosbuvir 3'-O-Phosphoramidate/Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate;sofosbuvir impurity Y008005-G | | CAS: | 1337482-15-1 | | MF: | C22H29FN3O9P | | MW: | 529.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1337482-15-1.mol |  |
| | Sofosbuvir IMpurity C Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | soluble in No data available | | pka | 9.39±0.10(Predicted) |
| | Sofosbuvir IMpurity C Usage And Synthesis |
| Uses | Sofosbuvir 5''-Desphosphate 3''-O-[(S)-Phosphate] is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
| | Sofosbuvir IMpurity C Preparation Products And Raw materials |
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