|
|
| | 7-Fluoro-4-hydroxy-2H-chromen-2-one Basic information |
| Product Name: | 7-Fluoro-4-hydroxy-2H-chromen-2-one | | Synonyms: | 7-Fluoro-4-hydroxy-1(2H)-benzopyran-2-one;7-Fluoro-4-hydroxy-2H-chromen-2-one;7-Fluoro-4-hydroxycoumarin;7-Fluoro-4-hydroxy-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 7-fluoro-4-hydroxy- | | CAS: | 2145-27-9 | | MF: | C9H5FO3 | | MW: | 180.13 | | EINECS: | | | Product Categories: | | | Mol File: | 2145-27-9.mol |  |
| | 7-Fluoro-4-hydroxy-2H-chromen-2-one Chemical Properties |
| Melting point | 220-225°C | | Boiling point | 339.4±42.0 °C(Predicted) | | density | 1.549±0.06 g/cm3(Predicted) | | pka | 4.50±1.00(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | 7-Fluoro-4-hydroxy-2H-chromen-2-one Usage And Synthesis |
| Uses | Reactant for:
- Enantioselective synthesis of polycyclic coumarins via in situ formed primary amine-imine-catalyzed asymmetric Michael addition to cyclic enones
- Preparation of dicoumarol analogs as inhibitors of human NAD(P)H quinone oxidoreductase-1 (NQO1) as agents active against human pancreatic and colon cancer cells
- Imidazolidinecarboxylic acid-catalyzed asymmetric Michael reaction with unsaturated ketones in a highly atom-economic catalytic one-step formation of optically active warfarin anticoagulant
- Asymmetric synthesis of functionalized α-keto esters and their hemiketal and hemiaminal derivatives via direct Michael addition with unsaturated α-keto esters catalyzed by bisoxazoline-copper(II) complexes
|
| | 7-Fluoro-4-hydroxy-2H-chromen-2-one Preparation Products And Raw materials |
|