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| | OXYTHIAMINE HYDROCHLORIDE Basic information |
| Product Name: | OXYTHIAMINE HYDROCHLORIDE | | Synonyms: | 5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE;5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE;Oxametholone Hydrochloride;hydroxythiaminechloridehydrochloride;hyl)-4-methyl-,chloride,monohydrochloride;OXYTHIAMINE CHLORIDE HYDROCHLORIDE;OXYTHIAMINE HCL;OXYTHIAMINE HYDROCHLORIDE | | CAS: | 614-05-1 | | MF: | C12H17Cl2N3O2S | | MW: | 338.25 | | EINECS: | | | Product Categories: | Biochemistry;Vitamin Derivatives;Vitamins | | Mol File: | 614-05-1.mol |  |
| | OXYTHIAMINE HYDROCHLORIDE Chemical Properties |
| Melting point | >190°C (subl.) | | storage temp. | -20°C | | solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| WGK Germany | 3 | | RTECS | XJ7034100 |
| | OXYTHIAMINE HYDROCHLORIDE Usage And Synthesis |
| Uses | thiamine antagonist | | Uses | Oxythiamine chloride hydrochloride is suitable for use:
- as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
- as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
- in the synthesis of oxythiamineH picrolonate salt
| | Definition | ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid. | | General Description | Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods. | | Biochem/physiol Actions | Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression. |
| | OXYTHIAMINE HYDROCHLORIDE Preparation Products And Raw materials |
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