| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
CAS:856436-16-3
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:JI6
CAS:856436-16-3
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Creative Enzymes
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| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
| Products Intro: |
Product Name:JAK3 Inhibitor VI
CAS:856436-16-3
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| | JAK3 INHIBITOR VI Basic information |
| | JAK3 INHIBITOR VI Chemical Properties |
| storage temp. | +2C to +8C | | form | Yellow solid |
| | JAK3 INHIBITOR VI Usage And Synthesis |
| General Description | A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2. | | Biochem/physiol Actions | Cell permeable: yes |
| | JAK3 INHIBITOR VI Preparation Products And Raw materials |
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