| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:GGTI-286
CAS:171744-11-9
Purity:98% Package:100 mg；5 mg；50 mg
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| | GGTI-286 Basic information |
| Product Name: | GGTI-286 | | Synonyms: | GGTI-286;N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;GGTI-286
(GGTI286);L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester | | CAS: | 171744-11-9 | | MF: | C23H31N3O3S | | MW: | 429.58 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | GGTI-286 Chemical Properties |
| Boiling point | 626.9±55.0 °C(Predicted) | | density | 1.164±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 9.81±0.10(Predicted) |
| | GGTI-286 Usage And Synthesis |
| Biological Activity | GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1]. | | References | [1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540. |
| | GGTI-286 Preparation Products And Raw materials |
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