2H4]-D,L-2-羟基戊二酸
| 中文名称 | 2H4]-D,L-2-羟基戊二酸 |
|---|---|
| 中文同义词 | |
| 英文名称 | C02630 |
| 英文同义词 | C02630;alpha-hydroxyglutarate;2,3-Dideoxypentaric Acid;a-Hydroxyglutaric Acid;DL-2-Hydroxyglutaric Acid;2-hydroxyglutarate;α-Hydroxyglutaric Acid |
| CAS号 | 2889-31-8 |
| 分子式 | C5H8O5 |
| 分子量 | 148.11 |
| EINECS号 | |
| 相关类别 | Aliphatics |
| Mol文件 | 2889-31-8.mol |
| 结构式 | ![2H4]-D,L-2-羟基戊二酸 结构式](CAS/20180808/GIF/2889-31-8.gif) |
2H4]-D,L-2-羟基戊二酸 性质
| 熔点 | 98-100 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| 沸点 | 394.2±27.0 °C(Predicted) |
| 密度 | 1.508±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：30mg/mL； PBS（pH 7.2）：10 mg/mL |
| 酸度系数(pKa) | 3.67±0.10(Predicted) |
α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。
Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively.
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases.
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.