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Product Name:Wortmannin-Rapamycin Conjugate
CAS:1067892-47-0
Purity:98% Package:1G;10G;100G Remarks:Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapa
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Product Name:Wortmannin-Rapamycin Conjugate
CAS:1067892-47-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:Wortmannin-Rapamycin Conjugate
CAS:1067892-47-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:Wortmannin-Rapamycin Conjugate
CAS:1067892-47-0
Purity:98% Package:500μg;1mg;5mg
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TargetMol Chemicals Inc.
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Product Name:Wortmannin-Rapamycin Conjugate
CAS:1067892-47-0
Purity:详情请点击官网 Package:1 mg
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| | Wortmannin-Rapamycin Conjugate Basic information |
| Product Name: | Wortmannin-Rapamycin Conjugate | | Synonyms: | Wortmannin-Rapamycin Conjugate;ATASUAOFUAOSAN-NVEIXTJJSA-N;Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate] | | CAS: | 1067892-47-0 | | MF: | C88H131N3O23 | | MW: | 1598.99 | | EINECS: | | | Product Categories: | | | Mol File: | 1067892-47-0.mol |  |
| | Wortmannin-Rapamycin Conjugate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid |
| | Wortmannin-Rapamycin Conjugate Usage And Synthesis |
| Description | Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors. |
| | Wortmannin-Rapamycin Conjugate Preparation Products And Raw materials |
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