DUOCARMYCIN
中文名称 | DUOCARMYCIN |
---|---|
中文同义词 | 化合物 T11119 |
英文名称 | DuocarMycin |
英文同义词 | DuocarMycin;Duocarmycin DM free base;Methanone, [(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl][5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]- |
CAS号 | 1116745-06-2 |
分子式 | C26H26ClN3O3 |
分子量 | 463.96 |
EINECS号 | |
相关类别 | |
Mol文件 | 1116745-06-2.mol |
结构式 |
DUOCARMYCIN 性质
沸点 | 712.9±60.0 °C(Predicted) |
---|---|
密度 | 1.345±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 9.47±0.40(Predicted) |
Daunorubicins/Doxorubicins
|
The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from
Streptomyces sp.
that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin shows cytotoxicity to several human cancer cells, with IC
50
of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-128915 | DUOCARMYCIN Duocarmycin DM free base | 1116745-06-2 | 5mg | 8800元 |
2024/01/25 | HY-128915 | Duocarmycin DM free base | 1 mg | 3520元 |