| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:AI-1 >=98% (HPLC)
CAS:75483-04-4
Purity:NULL Package:25mg Remarks:NULL
|
| Company Name: |
Abmole Bioscience Inc.
|
| Tel: |
021-50967598 02150967598 |
| Email: |
sales@abmole.cn |
| Products Intro: |
Product Name:AI-1
CAS:75483-04-4
Purity:>98% Package:5MG;10MG;25MG;50MG;100MG;500MG;1G;5G;10G
|
| Company Name: |
Nanjing Shizhou Biology Technology Co.,Ltd
|
| Tel: |
025-85563444 15850508050 |
| Email: |
purchase@synzest.com |
| Products Intro: |
Product Name:4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline
CAS:75483-04-4
Purity:95% Package:1g;5g;10g
|
| Company Name: |
Focus Biomolecules
|
| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:AI-1
CAS:75483-04-4
Purity:98% by HPLCNMR (Conforms) Package:$70.00/5mg;$280.00/25mg;
|
|
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Basic information |
| Product Name: | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline | | Synonyms: | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline;Ethyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate;4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester;AI-1;Nrf2 Activator II, AI-1;AI-1
(Nrf2 acticatior AI-1);Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem;AI-1 >=98% (HPLC) | | CAS: | 75483-04-4 | | MF: | C13H12ClNO3 | | MW: | 265.69 | | EINECS: | | | Product Categories: | | | Mol File: | 75483-04-4.mol |  |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Chemical Properties |
| Melting point | 90-92 °C | | Boiling point | 358.7±42.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥15mg/mL | | form | powder | | pka | -2.22±0.60(Predicted) | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 43 | | Safety Statements | 36/37 | | HS Code | 2933499090 |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Usage And Synthesis |
| Description | AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1?Cell permeable. | | Uses | AI-1 is an antioxidant response element (ARE) that activates Nrf2 by covalently modifying Keap1. AI-1 is a useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. | | References | 1) Hur?et al. (2010),?A small-molecule inducer of the antioxidant response element; Chem. Biol.,?17?537 |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Preparation Products And Raw materials |
|