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Dalfopristin+Quinupristin

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Company Name: A.T.CHEMICAL   
Tel: 0755-86655561 81899190
Email: Jeffreyxu@atchem.net
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Company Name: Service Chemical Inc.  
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Dalfopristin+Quinupristin Basic information
Product Name:Dalfopristin+Quinupristin
Synonyms:Dalfopristin+Quinupristin;3-Pyridinecarbonitrile, 2-amino-4-(3-chlorophenyl)-6-phenyl-
CAS:126202-89-9
MF:C18H12ClN3
MW:305.76
EINECS:
Product Categories:
Mol File:126202-89-9.mol
Dalfopristin+Quinupristin Structure
Dalfopristin+Quinupristin Chemical Properties
Melting point 226 °C
Boiling point 527.3±50.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
pka2.40±0.18(Predicted)
Safety Information
MSDS Information
Dalfopristin+Quinupristin Usage And Synthesis
Clinical UseA drug combination of the streptogramins, quinupristin and dalfopristin was approved for IV use in the treatment of infections caused by vancomycin-resistant Enterococcus faeci um bacteremia as well as skin/skin structure infections caused by MRSA and methicillin-sensitive Streptococcus pyogenes. Certain strains of E. faecium are resistant to essentially all other antibiotics, including vancomycin. The streptogramin type A compound dalfopristin binds to the 50S ribosomal subparticle, resulting in a conformational change in the substrate. It appears that dalfopristin binding creates a high-affinity binding site for quinupristin, accounting for the synergy.
Dalfopristin+Quinupristin Preparation Products And Raw materials
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