| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
CAS:6152-57-4
Purity:>99% by HPLC Package:1mg;5mg
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| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:O-Methylviridicatin
CAS:6152-51-4
Purity:>99% by HPLC Package:1mg;5mg
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| | AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Basic information |
| | AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid |
| | AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Usage And Synthesis |
| Uses | 3-O-Methylviridicatin is a metabolite produced by several species of Penicillium. Recently, 3-O-methylviridicatin was shown to be a strong inhibitor of TNFα-induced replication of HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. | | Biological Activity | 5 μm: blocks activation of the hiv long terminal repeat by tnf-α in hela cellso-methylviridicatin, a natural derivative of the alkaloid mycotoxin viridicatin, is produced by several species in the genus, penicillium. it is demonstrated that o-methylviridicatin, as an inhibitor, blocks the tumor necrosis factor alpha (tnfα)-induced replication of human immunodeficiency virus (hiv). tnfα increases the binding of the cellular transcription factor nf-κb to the hiv long terminal repeat (ltr), which directly triggers transcription of the latent provirus. | | in vitro | o-methylviridicatin had an inhibitory effect on the tnfα-triggered replication of hiv ltr in hela cells. in addition, o-methylviridicatin dose-dependently dampened virus production in the om-10.1 cell line, which was measured by the output of p24 core antigen into the culture medium. it was demonstrated that the suppressive effect of o-methylviridicatin was not reversed even if the concentration of tnfα was increased 10-fold [1]. | | IC 50 | 2.5 μm: inhibits virus production in om-10.1 cells (hl-60 promyelocytes infected with hiv-1) treated with tnf-α. | | references | [1]. heguy, a., cai, p., meyn, p., houck, d., russo, s., & michitsch, r. et al. isolation and characterization of the fungal metabolite 3-o-methylviridicatin as an inhibitor of tumour necrosis factor-induced human immunodeficiency virus replication. antiviral chemistry and chemotherapy. 1998; 9(2): 149-155. |
| | AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Preparation Products And Raw materials |
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