| Company Name: |
Suzhou Gopon Pharmaceutical Co., Ltd
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| Tel: |
133-5805-9751 |
| Email: |
gopon2012@gmail.com |
| Products Intro: |
Product Name:Canrenoate Potassium
Purity:99%， USP, EP, CP Package:25KG
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| Company Name: |
A.T.CHEMICAL
|
| Tel: |
0755-86655561 81899190 |
| Email: |
Jeffreyxu@atchem.net |
| Products Intro: |
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| | CANRENOATE POTASSIUM Basic information |
| | CANRENOATE POTASSIUM Chemical Properties |
| | CANRENOATE POTASSIUM Usage And Synthesis |
| Originator | Spiroctan,Boehringer
Mannheim,Switz.,1968 | | Uses | Aldosterone antagonist. | | Manufacturing Process | The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl-
17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts
of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling
point of the solvent under reflux overnight. The solution is then cooled and
filtered through approximately 200 parts of silica gel. The gel is successively
washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the
washings comprising 15% ethyl acetate are thereupon purified by
chromatography on a further quantity of silica gel, using benzene and ethyl
acetate as developing solvents. From the 15% ethyl acetate eluate there is
obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone,
melting at 148° to 151°C. The product solidifies above this melting point and
melts again at 165°C. | | Therapeutic Function | Aldosterone antagonist, Diuretic |
| | CANRENOATE POTASSIUM Preparation Products And Raw materials |
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