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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:C527
CAS:192718-06-2
Purity:98.00% Package:10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
CAS:192718-06-2
Purity:Min98% HPLC/GC Package:1g;1USD
Company Name: NewCan Biotech Limited
Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Products Intro: Product Name:2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione
CAS:192718-06-2
Purity:97% Package:mgs,gs,kgs
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:C527
CAS:192718-06-2
Purity:99% Package:$60.9/5mg;$100.9/10mg;$210.9/25mg;$350.9/50mg;$590.9/100mg;Bulk package Remarks:99%
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
CAS:192718-06-2
Purity:0.97 Package:mgs,gs,kgs Remarks:A900542
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Basic information
Product Name:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Synonyms:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;C527;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;C527 >=98% (HPLC);Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit;2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione
CAS:192718-06-2
MF:C17H8FNO3
MW:293.25
EINECS:
Product Categories:
Mol File:192718-06-2.mol
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Structure
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties
Boiling point 488.6±47.0 °C(Predicted)
density 1.433±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: soluble0.3mg/mL, clear (warmed)
pka-4.21±0.20(Predicted)
form powder
color faint yellow to dark yellow
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 46
WGK Germany 3
MSDS Information
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Usage And Synthesis
Biological ActivityC527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.
in vitro

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

target

0.88 μM (USP1)

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials
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