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MK-4101

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:MK-4101
CAS:935273-79-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:MK-4101
CAS:935273-79-3
Purity:>98% Package:300mg Remarks:BOC Sciences also provides custom synthesis services for MK-4101.
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:MK-4101
CAS:935273-79-3
Purity:99% Package:5KG;1KG Remarks:MK-4101
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:MK-4101
CAS:935273-79-3
Purity:98% Package:5mg Remarks:V2914
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:MK-4101
CAS:935273-79-3
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
MK-4101 Basic information
Product Name:MK-4101
Synonyms:MK-4101;5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole;MK4101;MK 4101;MK-4101;1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-;Apoptosis,inhibit,MK4101,Smoothened,MK-4101,MK 4101,Hedgehog,Inhibitor,Smo
CAS:935273-79-3
MF:C24H24F5N5O
MW:493.47
EINECS:
Product Categories:
Mol File:935273-79-3.mol
MK-4101 Structure
MK-4101 Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid
Safety Information
MSDS Information
MK-4101 Usage And Synthesis
Biological Activitymk-4101 is a hedgehog (hh) signaling pathway inhibitor.abnormal activation of the hedgehog (hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.
in vitromk-4101 was found to target the hh pathway in tumor cells, with the maximum inhibitory effect on gli1. mk-4101 could also induce the deregulation of cell cycle and block of dna replication in tumors. in addition, members of the igf and wnt signaling pathways were among the most highly deregulated genes by mk-4101, indicating that the interplay among hh, igf, and wnt was critical in hh-dependent tumorigenesis [1].
in vivoin a previous study, using neonatally irradiated ptch1(+/-) mice as a model of hh-dependent tumors, the in vivo effects of mk-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. results showed a potent antitumor activity of mk-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. moreover, beside antitumor activity on transplanted tumors, mk-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].
target
TargetValue
SMO
()
IC 501.5 μmol/l for in mouse light ii cells by gli_luc assay
references[1] filocamo g et al. mk-4101, a potent inhibitor of the hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. mol cancer ther. 2016 jun;15(6):1177-89.
MK-4101 Preparation Products And Raw materials
Tag:MK-4101(935273-79-3) Related Product Information
Ethyl nonafluorobutyl ether Cyclobutyl bromide Obeticholic Acid XL147 4-Piperidinol, 4-methyl-, hydrochloride (1:1) Z-ALA-OSU mk-1064 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK 0557 MK-0812 (Succinate) MKC9989 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102) MK-8998 MK8745 MK-5172 MK-2206 2HCl