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(-)-3,4-Dihydroxynorephedrine

(-)-3,4-Dihydroxynorephedrine Basic information
Product Name:(-)-3,4-Dihydroxynorephedrine
Synonyms:4-[2-AMINO-1-HYDROXYPROPYL]-1,2-BENZENEDIOL;(-)3,4-DIHYDROXYNOREPHEDRINE;(-)-3,4-DIHYDROXYNOREPHREDRINE;CORBADRINE;LEVONORDEFRIN;Dihydroxyphenylpropanolamine;Dioxynorepinephrine;Isoadrenaline
CAS:829-74-3
MF:C9H13NO3
MW:183.2
EINECS:
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:829-74-3.mol
(-)-3,4-Dihydroxynorephedrine Structure
(-)-3,4-Dihydroxynorephedrine Chemical Properties
Melting point 212-215°C dec.
alpha D25 -31.0° (c = 0.5 in 0.01N HCl)
Boiling point 431.6±40.0 °C(Predicted)
density 1.328±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka9.59±0.10(Predicted)
form powder
color white to light brown
Merck 13,6725
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1 / PGII
WGK Germany 3
HS Code 2922504500
ToxicityLD50 in mice (mg/kg): 12.6 i.v. (Luduena)
MSDS Information
ProviderLanguage
SigmaAldrich English
(-)-3,4-Dihydroxynorephedrine Usage And Synthesis
Chemical PropertiesWhite Powder
UsesA vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics
UsesVasoconstrictor;Adrenergic receptor agonist
DefinitionChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant.
Brand nameNeo-Cobefrin (Cook-Waite).
(-)-3,4-Dihydroxynorephedrine Preparation Products And Raw materials
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