| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-(4-AcetaMidophenyl)indoMethacin AMide
CAS:261766-23-8
Package:500Mg,50Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
CAS:261766-23-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:N-(4-Acetamidophenyl)indomethacinamide
CAS:261766-23-8
Purity:98.0% Package:5MG; 25MG; 100MG; 1G
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| | N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Basic information |
| Product Name: | N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE | | Synonyms: | N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-4ACETIA;N-4AIA;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl- | | CAS: | 261766-23-8 | | MF: | C27H24ClN3O4 | | MW: | 489.95 | | EINECS: | | | Product Categories: | Inhibitors;Aromatics;Heterocycles | | Mol File: | Mol File |  |
| | N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties |
| Melting point | 256-257°C | | storage temp. | −20°C | | solubility | DMSO: ≥15 mg/mL | | form | crystalline | | color | Pale Yellow |
| | N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Usage And Synthesis |
| Description | N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2. | | Chemical Properties | Pale Yellow Solid | | Uses | An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively | | Definition | ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole. | | references | [1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70. |
| | N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials |
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