| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-(3-Pyridyl)indoMethacin AMide
CAS:261755-29-4
Package:500Mg,50Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:N-(3-PYRIDYL)-INDOMETHACIN AMIDE
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:N-(3-Pyridyl)indoMethacin AMide;N-(3-Pyridyl)-1-p-chlorobenzoyl-5-Methoxy-2-Methylindole-3-acetaMide; 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide
CAS:261755-29-4
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:N-(3-Pyridyl)indomethacinamide
CAS:261766-29-4
Purity:98.0% Package:5MG; 25MG; 100MG; 1G
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| | N-(3-PYRIDYL)-INDOMETHACIN AMIDE Basic information |
| Product Name: | N-(3-PYRIDYL)-INDOMETHACIN AMIDE | | Synonyms: | N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-INDOMETHACIN AMIDE;N-3PYIA;N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-3-pyridinyl-;Indomethacin N-Pyridyl Impurity | | CAS: | 261766-29-4 | | MF: | C24H20ClN3O3 | | MW: | 433.89 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | Mol File |  |
| | N-(3-PYRIDYL)-INDOMETHACIN AMIDE Chemical Properties |
| storage temp. | −20°C | | solubility | ≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide | | form | crystalline solid |
| | N-(3-PYRIDYL)-INDOMETHACIN AMIDE Usage And Synthesis |
| Uses | An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM. | | Biological Activity | n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1]. | | references | [1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70. |
| | N-(3-PYRIDYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials |
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