| Company Name: |
Shanghai Witofly Chemical Co.,Ltd
|
| Tel: |
|
| Email: |
sales@witofly.com |
| Products Intro: |
Product Name:SMoothened Agonist, HCl
CAS:364590-63-6
Purity:98% HPLC Package:1KG
|
| Company Name: |
ChemStrong Scientific Co.,Ltd
|
| Tel: |
0755-0755-66853366 13670046396 |
| Email: |
sales@chem-strong.com |
| Products Intro: |
Product Name:Hh-Ag 1.3
CAS:364590-63-6
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
Finetech Industry Limited
|
| Tel: |
027-87465837 19945049750 |
| Email: |
sales@finetechnology-ind.com |
| Products Intro: |
Product Name:SAG dihydrocloride
CAS:364590-63-6
Purity:98% Package:1g,10g,25g,500g,1kg
|
|
| | Hh-Ag 1.3 Basic information |
| Product Name: | Hh-Ag 1.3 | | Synonyms: | 3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Smoothened Agonist, HCl;SAG . dihydrochloride (water soluble);Hh-Ag 1.3;3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride;Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-;Frizzled6 agonist SAG1.3 | | CAS: | 364590-63-6 | | MF: | C28H28ClN3OS | | MW: | 490.06 | | EINECS: | | | Product Categories: | | | Mol File: | 364590-63-6.mol |  |
| | Hh-Ag 1.3 Chemical Properties |
| Boiling point | 688.6±55.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | pka | 10?+-.0.40(Predicted) | | form | White to off-white solid. | | Water Solubility | Soluble in water. | | Sensitive | Light Sensitive & Hygroscopic |
| | Hh-Ag 1.3 Usage And Synthesis |
| Uses | Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo. |
| | Hh-Ag 1.3 Preparation Products And Raw materials |
|