1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮
| 中文名称 | 1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮 |
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| 中文同义词 | 1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮;1-[4-AMINO-7-(3-HYDROXYPROPYL)-5-(4-METHYLPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]-2-CHLORO-ETHANONE (>90%) |
| 英文名称 | 1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone |
| 英文同义词 | 1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone;1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone (>90%);1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloroethanone;1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone;1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2;1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-ethanone (>Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-;Clomipramina |
| CAS号 | 821794-90-5 |
| 分子式 | C18H19ClN4O2 |
| 分子量 | 358.82 |
| EINECS号 | |
| 相关类别 | Akt;mTOR;PI3K;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 821794-90-5.mol |
| 结构式 | ![1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮 结构式](CAS/GIF/821794-90-5.gif) |
1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮 性质
| 熔点 | 170-172°C |
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| 沸点 | 647.5±55.0 °C(Predicted) |
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿、甲醇 |
| 酸度系数(pKa) | 14.43±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅黄色 |
CMK是 RSK2激酶抑制剂，与FMK相比，具有相似的效力但化学稳定性较低。
CMK inhibits the growth of Cdc5 (L158G) with IC 50 of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC 50 of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration.
安全信息
| 海关编码 | 2933998090 |
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