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| | AIM-100 Basic information |
| Product Name: | AIM-100 | | Synonyms: | AIM-100;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine;AIM 100;AIM100;Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-;(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer;(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine | | CAS: | 873305-35-2 | | MF: | C23H21N3O2 | | MW: | 371.43 | | EINECS: | | | Product Categories: | API | | Mol File: | 873305-35-2.mol |  |
| | AIM-100 Chemical Properties |
| Boiling point | 552.9±50.0 °C(Predicted) | | density | 1.243±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming | | form | Powder | | pka | 4.62±0.40(Predicted) |
| | AIM-100 Usage And Synthesis |
| Uses | AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth. | | Biological Activity | aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2]. | | storage | Store at +4°C | | references | 1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393. |
| | AIM-100 Preparation Products And Raw materials |
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