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| Product Name: | SHA 68 | | Synonyms: | SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl- | | CAS: | 847553-89-3 | | MF: | C26H24FN3O3 | | MW: | 445.49 | | EINECS: | | | Product Categories: | | | Mol File: | 847553-89-3.mol |  |
| | SHA 68 Chemical Properties |
| Boiling point | 727.8±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml | | form | A crystalline solid | | pka | 13.32±0.40(Predicted) |
| | SHA 68 Usage And Synthesis |
| Description | SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats. | | Uses | SHA 68 is a selective neuropeptide S antagonist. | | storage | Store at +4°C |
| | SHA 68 Preparation Products And Raw materials |
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