CPPG
| 中文名称 | CPPG |
|---|---|
| 中文同义词 | 化合物 T10880 |
| 英文名称 | CPPG |
| 英文同义词 | CPPG;(+/-)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE;(RS)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE;(RS)-CPPG;(RS)-α-Cyclopropyl-4-phosphonophenylglycine;Benzeneacetic acid, α-amino-α-cyclopropyl-4-phosphono-;rac-CPPG;2-Amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid |
| CAS号 | 183364-82-1 |
| 分子式 | C11H14NO5P |
| 分子量 | 271.21 |
| EINECS号 | |
| 相关类别 | Glutamate receptor |
| Mol文件 | 183364-82-1.mol |
| 结构式 |  |
CPPG 性质
| 储存条件 | Store at RT |
|---|---|
| 溶解度 | 在水中的溶解度>5mg/mL |
| 形态 | 固体 |
| 颜色 | 白色至米色 |
CPPG ((RS)-CPPG) 是一种有效的 II/III 型 mGlu 受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组（(IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。
|
group III mGlu receptors 2.2 nM (IC 50 ) |
group II mGlu receptors 46.2 nM (IC 50 ) |
CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC 50 =2.2 nM)- and L-CCG-I (IC 50 =46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells.