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| | SB 242084 (hydrochloride) Basic information |
| | SB 242084 (hydrochloride) Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | Ethanol:1.0(Max Conc. mg/mL);2.14(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);21.38(Max Conc. mM)
DMSO:59.63(Max Conc. mg/mL);127.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);64.13(Max Conc. mM) | | form | A crystalline solid |
| | SB 242084 (hydrochloride) Usage And Synthesis |
| Description | Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that activates specific receptors located primarily in the gut and central nervous system. SB-242084 is an antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors. In vivo, it is brain penetrant and has significant anxiolytic activity, without sedative, proconvulsant, or hyperphagic properties. SB-242084 has been used extensively in animal research to evaluate, for example, 5-HT2C receptor agonists and neurotransmitter receptor interactions in mice. | | Uses | SB 242084 Hydrochloride is an antagonist of the SR-2C. | | Definition | ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator. | | storage | Desiccate at +4°C |
| | SB 242084 (hydrochloride) Preparation Products And Raw materials |
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