Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- manufacturers
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| | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- Basic information |
| Product Name: | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- | | Synonyms: | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-;(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid monosodium salt;Sodium ursodesoxycholate;URSODEOXYCHOLIC ACID SODIUM SALT USP/EP/BP;UDCA Na;Ursodeoxycholate sodium;Ursodeoxycholic acid sodium;gastrointestinal diseases,lipid metabolism,Ursodeoxycholate,GPBAR1,Ursodeoxycholic acid sodium,intestinal barrier integrity,NR1H4,Ursodeoxycholic acid,G-protein coupled receptor 19,hepatic,UCDA,inhibit,oral,GPCR19,Inhibitor,G protein-coupled Bile Acid Receptor 1,Endogenous Metabolite,Ursodiol,FXR,secondary bile acid,TGR5 | | CAS: | 2898-95-5 | | MF: | C24H39NaO4 | | MW: | 414.55383 | | EINECS: | | | Product Categories: | 2898-95-5 | | Mol File: | 2898-95-5.mol |  |
| | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml | | form | A crystalline solid | | InChIKey | WDFRNBJHDMUMBL-LEMNXDLSNA-M | | SMILES | [Na+].[C@H]1(O)C[C@]2([H])[C@](C)(CC1)C1C(C3[C@@](CC1)(C)[C@@H]([C@H](C)CCC([O-])=O)CC3)[C@@H](O)C2 |&1:1,4,6,13,17,18,27,r| |
| | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- Usage And Synthesis |
| Description | Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis. |
| | Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- Preparation Products And Raw materials |
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