MENSACARCIN
| 中文名称 | MENSACARCIN |
|---|---|
| 中文同义词 | 化合物 T12003 |
| 英文名称 | Mensacarcin |
| 英文同义词 | Mensacarcin;(1R,2S,3S,4S,4aS,9aS,10S)-1,2,3,4-Tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyloxiranyl]carbonyl]-4a,9a-epoxyanthracen-9(10)-one;4a,9a-Epoxyanthracen-9(10)-one, 1,2,3,4-tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyl-2-oxiranyl]carbonyl]-, (1R,2S,3S,4S,4aS,9aS,10S)- |
| CAS号 | 808750-39-2 |
| 分子式 | C21H24O9 |
| 分子量 | 420.40986 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 808750-39-2.mol |
| 结构式 |  |
MENSACARCIN 性质
| 沸点 | 656.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.53±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：可溶，甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.50±0.70(Predicted) |
| 颜色 | 白色至类白色 |
|
Traditional Cytotoxic Agents
|
Mensacarcin (0-100 μM; 24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells.
Mensacarcin (2-50 μM; 15 hours) induces rapid apoptotic cell death in melanoma cells.
Mensacarcin exhibits potent cytostatic properties (mean of 50% growth inhibition=0.2 μM) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling
Streptomyces
bacteria. Mensacarcin impairs mitochondrial function in melanoma cells.
Cell Viability Assay
| Cell Line: | SK-Mel-28 and SK-Mel-5 melanoma cells, HCT-116 colon cancer cells |
| Concentration: | 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 24 hours |
| Result: | Induced concentration- and time-dependent cell death in the two tested melanoma cell lines. HCT-116 colon carcinoma cells were strongly inhibited. |
Western Blot Analysis
| Cell Line: | SK-Mel-28, SK-Mel-5 cells |
| Concentration: | 2, 10, 50 μM |
| Incubation Time: | 15 hours |
| Result: | Induced the formation of 89-kDa PARP-1 fragments as well as caspase-3 activation in SK-Mel-28 and SK-Mel-5 beginning between 6 and 15 h after exposure. |