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| | L 2-401 Basic information |
| Product Name: | L 2-401 | | Synonyms: | 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione;CCG 50014;L 2-401;1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-;4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione;CCG50014;CCG 50014;CS-563;CCG-50014 >=98% (HPLC) | | CAS: | 883050-24-6 | | MF: | C16H13FN2O2S | | MW: | 316.35 | | EINECS: | 604-604-1 | | Product Categories: | Inhibitors | | Mol File: | 883050-24-6.mol |  |
| | L 2-401 Chemical Properties |
| density | 1.398±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige |
| | L 2-401 Usage And Synthesis |
| Description | CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα0, while blocking GTPase activity and Gα0-dependent translocation of RGS4 to the membrane. |
| | L 2-401 Preparation Products And Raw materials |
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