|
|
| | Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Basic information |
| | Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM) | | form | A crystalline solid |
| | Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Usage And Synthesis |
| Description | L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM. | | Uses | L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design. |
| | Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Preparation Products And Raw materials |
|