| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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021-58950125 |
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info@chemexpress.com |
| Products Intro: |
Product Name:AICAR (phosphate)
CAS:681006-28-0
Purity:>98% Package:520RMB/50mg
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| | AICAR (phosphate) Basic information |
| Product Name: | AICAR (phosphate) | | Synonyms: | AICAR (phosphate);5-Amino-1-ribosylimidazole-4-carboxamide phosphate;AICAR (Acadesine) phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR phosphate
(Acadesine phosphate;Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE | | CAS: | 681006-28-0 | | MF: | C9H17N4O9P | | MW: | 356.23 | | EINECS: | | | Product Categories: | | | Mol File: | 681006-28-0.mol |  |
| | AICAR (phosphate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | AICAR (phosphate) Usage And Synthesis |
| Biological Activity | aicar phosphate （acadesine）is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1]. | | references | [1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9. |
| | AICAR (phosphate) Preparation Products And Raw materials |
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