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| | YM 26734 Basic information |
| Product Name: | YM 26734 | | Synonyms: | YM 26734;1-Dodecanone, 1,1'-(5-(3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl)-2,4,6-trihydroxy-1,3-phenylene)bis-;4-(3,5-Didodecanoyl-2,4,6-trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman;1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone;1-[3-dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]phenyl]dodecan-1-one | | CAS: | 144337-18-8 | | MF: | C45H62O8 | | MW: | 730.97 | | EINECS: | | | Product Categories: | | | Mol File: | 144337-18-8.mol |  |
| | YM 26734 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Powder |
| | YM 26734 Usage And Synthesis |
| Uses | YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 which is a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions. | | Biological Activity | Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 μ M for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 , cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema. | | storage | Store at -20°C |
| | YM 26734 Preparation Products And Raw materials |
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