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| | Ripasudil Basic information |
| Product Name: | Ripasudil | | Synonyms: | k115 free base;Ripasudil;4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline;RIPASUDIL FREE BASE;K 115 FREE BASE;K115 FREE BASE;CS-1564;K-115, Ripasudil;Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-;RIPASUDIL HYDROCHLOIDE | | CAS: | 223645-67-8 | | MF: | C15H18FN3O2S | | MW: | 323.39 | | EINECS: | | | Product Categories: | | | Mol File: | 223645-67-8.mol |  |
| | Ripasudil Chemical Properties |
| Boiling point | 497.2±55.0 °C(Predicted) | | density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Soluble in DMSO | | pka | 9.70±0.40(Predicted) |
| | Ripasudil Usage And Synthesis |
| Description | Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing. | | Definition | ChEBI: Ripasudil is a member of isoquinolines. |
| | Ripasudil Preparation Products And Raw materials |
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