棕榈酰肉碱
| 中文名称 | 棕榈酰肉碱 |
|---|---|
| 中文同义词 | 棕榈酰-L-左旋肉碱 |
| 英文名称 | PALMITOYL CARNITINE |
| 英文同义词 | (-)-[(R)-3-Carboxylato-2-(palmitoyloxy)propyl]trimethylaminium;(2R)-3-Carboxylato-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium;Hexadecanoylcarnitine;Palmitoyl L-carnitine;Palmitylcarnitine;C02990;1-PropanaMiniuM, 3-carboxy-N,N,N-triMethyl-2-[(1-oxohexadecyl)oxy]-, inner salt, (2R)-;O-palmitoyl-L-carnitine |
| CAS号 | 2364-67-2 |
| 分子式 | C23H45NO4 |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2364-67-2.mol |
| 结构式 |  |
棕榈酰肉碱 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 旋光性 (optical activity) | [α]/D -17±2°, c = 1 in methanol |
| BRN | 4152034 |
L-Palmitoylcarnitine 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine 通过与 Kir6.2 的相互作用抑制 KATP 通道活性，而不影响单通道电导。
|
Kir6.2
|
Human Endogenous Metabolite
|
L-Palmitoylcarnitine (1 µM) inhibits K
ATP
channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC
50
fell from 62 to 30 µM).
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K
ATP
channel function mainly through the interaction with endogenous PI cascade, especially PIP2.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2022/07/01 | HY-113147 | 棕榈酰肉碱 L-Palmitoylcarnitine | 2364-67-2 | 5 mg | 1500元 |