Nalfurafine hydrochloride
Price | $1 |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1ton |
Update Time: | 2020-01-13 |
Product Details
Product Name: Nalfurafine hydrochloride | CAS No.: 152658-17-8 |
EC-No.: 200-258-5 | Min. Order: 1g |
Purity: 99% | Supply Ability: 1ton |
Release date: 2020/01/13 | |
contact: Mary@coreychem.com |
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Common Name
Nalfurafine hydrochloride
CAS Number
152658-17-8
Molecular Weight
513.025
Density
N/A
Boiling Point
N/A
Molecular Formula
C28H33ClN2O5
Melting Point
N/A
MSDS
N/A
Flash Point
N/A
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Use of Nalfurafine hydrochloride
Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan.
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Name
Nalfurafine Hydrochloride
Synonym
More Synonyms
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Description
Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan.
Related Catalog
Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease
In Vivo
In mice with experimental dry skin, nalfurafine abolished spontaneous scratching but had no effect on alloknesis[1]. A single administration of subcutaneous TRK-820 significantly increased spontaneous ipsilateral rotational behavior of hemi-parkinsonian rats at 30 μg/kg though the efficacy is moderate and also significantly inhibited L-DOPA-induced dyskinesia at 10 and 30 μg/kg; this inhibition is reversed in the presence of nor-binaltorphimine, a kappa opioid receptor antagonist[2]. TRK-820 dose-dependently inhibited phencyclidine-induced rat hyperlocomotion. TRK-820 dose-dependently attenuated the biochemical changes of both dopamine and serotonin in the prefrontal cortex of rats treated with phencyclidine without affecting their basal levels in normal rats[3].
Animal Admin
Rats: Nalfurafine is given to male Sprague-Dawley rats at volume of 1 mL/kg. After collecting control samples for 80 min, PCP (10 mg/kg, i.p.) is administered to the rats, and then the collection of dialysate is continued for 180 min. Pre-treatment with TRK-820 or vehicle is performed subcutaneously 5 min before the administration of PCP. Dopamine and serotonin levels in the dialysate are quantified by high-performance liquid chromatography[2]. Mice: Chronic dry skin on the nape of the neck is induced on the C57BL/6 mice. Nalfurafine (20 μg/kg) or saline is administered. Then alloknesis testing is conducted[1].
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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