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Postion:Product Catalog >Biochemical Engineering>Chinese Herbs>Bilirubin
Bilirubin
  • Bilirubin
  • Bilirubin

Bilirubin NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-27

Product Details

Product Name: Bilirubin CAS No.: 635-65-4
Min. Order: 1KG Purity: 98%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/27
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information

Names

Namebilirubin
SynonymMore Synonyms

 bilirubin Biological Activity

DescriptionBilirubin is a yellow breakdown product of heme catabolism.
Related Catalog
Natural Products >> Acids and Aldehydes
Research Areas >> Cardiovascular Disease
Target

Human Endogenous Metabolite

In VitroUnconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2].
References

[1]. Lu RN, et al. Unconjugated Bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J Thromb Haemost. 2015 Jun;13(6):1064-72.

[2]. Mölzer C, et al. Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. J Nat Prod. 2013 Oct 25;76(10):1958-65.

 Chemical & Physical Properties

Density1.2163
Boiling Point641.7°C
Melting Point192 °C
Molecular FormulaC33H36N4O6
Molecular Weight584.662
Flash Point478.1±37.1 °C
Exact Mass584.263489
PSA164.38000
LogP3.15
Vapour Pressure0.0±0.3 mmHg at 25°C
Index of Refraction1.640
Storage condition−20°C
StabilityStable. Refrigerate.

 MSDS

bilirubin MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • DU3038000

  • CHEMICAL NAME :

  • Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19 -dioxo- 3,18-divinyl-

  • CAS REGISTRY NUMBER :

  • 635-65-4

  • BEILSTEIN REFERENCE NO. :

  • 0074376

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 8

  • MOLECULAR FORMULA :

  • C33-H36-N4-O6

  • MOLECULAR WEIGHT :

  • 584.73

  • WISWESSER LINE NOTATION :

  • T5VMYTJ D1 E1U1 CU1- ET5MYTJ C2VQ D1 BU1- ET5MYTJ C1 D2VQ BU1- ET5MVTJ C1 D1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >15 gm/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity)

  • REFERENCE :

  • ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >2 gm/kg

  • TOXIC EFFECTS :

  • Gastrointestinal - other changes

  • REFERENCE :

  • ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985 ** REPRODUCTIVE DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 175 mg/kg

  • SEX/DURATION :

  • female 9-15 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

  • REFERENCE :

  • AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 127,497,1977

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • DOSE :

  • 25 mg/kg

  • SEX/DURATION :

  • female 12 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - other effects to embryo

  • REFERENCE :

  • AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 127,497,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81726 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1390 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81726 No. of Facilities: 1176 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 12638 (estimated) No. of Female Employees: 9389 (estimated)

 Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXn
Risk PhrasesR62
Safety Phrases22-24/25-36-26
RIDADRNONH for all modes of transport
WGK Germany2
RTECSDU3038000
HS Code29339990

 Synthetic Route

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~82%

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bilirubin

CAS#:635-65-4

Literature: Monti, Diego; Speranza, Giovanna; Manitto, Paolo Gazzetta Chimica Italiana, 1982 , vol. 112, # 9/10 p. 361 - 366
Article illustration

Bilirubin dimet...

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~%

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bilirubin

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Literature: Monatshefte fur Chemie, , vol. 145, # 3 p. 465 - 482
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3,3'-[2-(1-merc...

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~%

Article illustration

bilirubin

CAS#:635-65-4

Literature: Gazzetta Chimica Italiana, , vol. 112, # 9/10 p. 361 - 366

 Precursor & DownStream

Precursor  8

Previous 1/2 Next

  • Article illustration CAS#:35677-91-9
    18-devinyl-18-(...

  • Article illustration CAS#:19792-68-8
    Bilirubin dimet...

  • Article illustration CAS#:66735-42-0
    3,3'-[2-(1-merc...

  • Article illustration CAS#:59614-72-1
    18-devinyl-18-[...

DownStream  9

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  • Article illustration CAS#:54474-50-9
    2,4-Dimethyl-3-...

  • Article illustration CAS#:517-22-6
    2,4-Dimethyl-3-...

  • Article illustration CAS#:19792-68-8
    Bilirubin dimet...

  • Article illustration CAS#:20189-42-8
    2-ethyl-3-methy...

 Customs

HS Code29339990



2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621










Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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