GABOXADOL HYDROCHLORIDE

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GABOXADOL HYDROCHLORIDE Basic information

Product Name: GABOXADOL HYDROCHLORIDE

Synonyms: 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate;4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride;THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE;THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride;Einecs 285-687-7;Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride;Gaboxadol hydrochloride solid, >=98% (HPLC);4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)

CAS: 85118-33-8

MF: C6H9ClN2O2

MW: 176.6

EINECS: 285-687-7

Product Categories:

Mol File: 85118-33-8.mol

GABOXADOL HYDROCHLORIDE Structure

GABOXADOL HYDROCHLORIDE Chemical Properties

Melting point 236 °C

storage temp. Keep in dark place,Inert atmosphere,Room temperature

solubility ethanol: soluble0.91mg/mL

form solid

color white

Merck 14,4321

Safety Information

Safety Statements 22-24/25

WGK Germany 3

RTECS NY3396800

HS Code 2934.99.9001

MSDS Information

GABOXADOL HYDROCHLORIDE Usage And Synthesis

Uses GABAergic Agonist

Uses Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites .

Uses As a molecular probe to study GABA receptors.

Uses Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

General Description Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.