Irinotecan hydrochloride trihydrate NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-09-11 |
Product Details
| Product Name: Irinotecan hydrochloride trihydrate | CAS No.: 136572-09-3 |
| EC-No.: 603-967-2 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/09/11 |
| CAS: | 136572-09-3 |
| MF: | C33H45ClN4O9 |
| MW: | 677.18 |
| EINECS: | 603-967-2 |
| Product Categories: | Inhibitors;Anticancer;API;Anti-cancer&immunity |
| Mol File: | 136572-09-3.mol |
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| Irinotecan hydrochloride trihydrate Chemical Properties |
| Melting point | 250-256°C (dec.) |
| Boiling point | 257°C(lit.) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). |
| form | White solid. |
| color | Yellow |
| Water Solubility | Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming |
| Merck | 14,5091 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
| Irinotecan hydrochloride trihydrate Usage And Synthesis |
| Description | Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3 |
| Chemical Properties | White powder |
| Uses | Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor. |
| Definition | ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. |
| Brand name | Camptosar (Pharmacia &Upjohn) . |
| Hazard | Moderately toxic by ingestion. |
| References | 1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert |
Packing &shipping&Payment
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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China- Since: 2017-12-08
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