Terbinafine

Terbinafine is an antifungal drug CAS:91161-71-6

Terbinafine hydrochloride a synthetic allyla antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.  
Terbinafine HCl a member of the allyl class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis.  
Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.

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