ChemicalBook >>Triamcinolone acetonide>>9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide(76-25-5)

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide(76-25-5)

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide(76-25-5)
Product IdentificationBack to Contents
【Product Name】

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
【Synonyms】

2-Amino-5-methylbenzoic acid
2-Carboxy-4-methylaniline
5-Methyl-2-aminobenzoic acid
5-Methylanthranilic acid
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
9-a-fluoro-11-b,21-dihydroxy-16-a,17-a-isopropylidenedioxypregna-1,4-diene-3,20-dione
9a-Fluoro-16a,17a-isopropylidenedihydroxyprednisolone
9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
Kenalog
Polcortoon
【CAS】

2941-78-8
【CAS】

76-25-5
【Formula】

C24H31FO6
【Formula】

C8H9NO2
【Molecular Weight】

434.5
【Molecular Weight】

151.16
【EINECS】

200-948-7
【EINECS】

220-932-3
【RTECS】

TU3920000
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,9728
【Beilstein/Gmelin】

1101527
【Beilstein/Gmelin】

60069
【Beilstein Reference】

5-19-06-00568
【Beilstein Reference】

4-14-00-01357
Physical and Chemical PropertiesBack to Contents
【Appearance】

Beige - light brown powder.
【Solubility in water】

Insoluble
【Solubility in water】

Very soluble
【Melting Point】

274
【Boiling Point】

317
【Boiling Point】

577
【Vapor Pressure】

0.0002 (25 C)
【Vapor Pressure】

1E-15 (25 C)
【pKa/pKb】

2.08 (pKa)
【pKa/pKb】

12.69 (pKs)
【Partition Coefficient】

1.67
【Heat Of Vaporization】

58.9 kJ/mol
【Heat Of Vaporization】

99.2 kJ/mol
【Usage】

A synthetic corticosteroid. Used for replacement therapy in people whose adrenal glands are not producing enough natural steroids (adrenal insufficiency) and decreasing inflammation in certain disease states. .
【Usage】

Metabolic antagonist.
First Aid MeasuresBack to Contents
【Ingestion】

Get medical aid. Wash mouth out with water.
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician.
【Inhalation】

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
【Inhalation】

Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】

Causes skin irritation.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Skin】

In case of contact, immediately wash skin with soap and copious amounts of water.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
【Eyes】

Causes eye irritation.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed.
【Storage】

Store in a cool, dry place. Store in a tightly closed container.
【Handling】

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Hazards IdentificationBack to Contents
【Ingestion】

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
【Inhalation】

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
【Skin】

May cause skin irritation. May be harmful if absorbed through the skin.
【Eyes】

May cause eye irritation.
【Ingestion】

May be harmful if swallowed.
【Hazards】

Emits toxic fumes under fire conditions.
【EC Risk Phrase】

R 36/37/38
【EC Safety Phrase】

S 26 36
【EC Safety Phrase】

22 24/25
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Protective gloves. Chemical safety goggles.
【Personal Protection】

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

Wear dust mask.
【Respirators】

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】

Avoid contact and inhalation. Target organ(s): Endocrine system.
Fire Fighting MeasuresBack to Contents
【Flash Point】

145
【Flash Point】

303
【Fire Fighting】

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
【Small spills/leaks】

Vacuum or sweep up material and place into a suitable disposal container.
Stability and ReactivityBack to Contents
【Stability】

No data.
【Stability】

Stable at normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Carbon monoxide, Carbon dioxide, Hydrogen fluoride.
【Decomposition】

Carbon monoxide, oxides of nitrogen, carbon dioxide.
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