ChemicalBook >>Ramatroban>>3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid(116649-85-5)

3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid(116649-85-5)

3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid(116649-85-5)
Product IdentificationBack to Contents
【Product Name】

3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid
【Synonyms】

3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)-
【CAS】

116649-85-5
【Formula】

C21H21FN2O4S
【Molecular Weight】

416.47
【Merck】

12,10455
Physical and Chemical PropertiesBack to Contents
【Appearance】

Crystalline solid.
【Solubility in water】

0.5 g/L (25 C)
【Vapor Pressure】

4.9E-18 (25 C)
【Density】

1.43 g/cm3
【pKa/pKb】

4.60 (pKa)
【Partition Coefficient】

4.09
【Usage】

A thromboxane receptor antagonist indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma.
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by medical personnel.
【Inhalation】

If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate medical attention.
【Skin】

In case of skin contact, immediately wash skin with soap and plenty of water. Remove contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
【Eyes】

In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any contact lenses and continue flushing for at least 20 minutes. Have eyes examined and tested by medical personnel.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Wear a NIOSH/MSHA approved self-contained breathing apparatus and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).
【Exposure Effects】

May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation. The toxicological properties of this compound have not been fully evaluated.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH approved or equivalent), and full protective gear to prevent contact with skin and eyes. Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray when fighting fires involving this material.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Vacuum or sweep up material and place in disposal container. Avoid raising dust. After removal, ventilate contaminated area and flush thoroughly with water.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
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