2-Amino-2-methyl-1-propanol: Uses and Toxicity

2-amino-2-methyl-1-propanol appears as a clear light colored liquid. Insoluble in water and about the same density as water. Flash point 172℉.

Uses

2-amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It is considered safe as currently used in amounts of 2% or less in cosmetic formulas. Aminomethyl propanol can penetrate the skin's uppermost layers, but does not go further, meaning it does not get into the body.

Toxicity

2-amino-2-methyl-1-propanol is of low acute toxicity. The undiluted substance causes corrosion of the eyes and severe skin irritation. In guinea pigs, 2-amino-2-methyl-1-propanol is not sensitizing. After short-term and repeated administration of oral doses of the substance, the liver was shown to be the target organ. The liver-specific serum enzyme activities are increased and histopathological alterations are seen in the liver. 2-Amino-2-methyl-1-propanol can cause damage and haemorrhage in the gastrointestinal mucosa. The hydrochloride is less toxic than the free base.