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Adenosine Ep Impurity A---Adenine

Jul 11，2023

Adenine (A) is a nucleotide base found in DNA, alongside cytosine (C), guanine (G), and thymine (T). It is also known as one of the impurities in Adenosine Ep.

Adenosine is a purine nucleoside found in DNA. It consists of adenine bonded to a ribose sugar molecule. Adenosine is essential for various biological processes and exists in different forms, including ATP, ADP, and AMP, which are involved in energy transfer. Additionally, adenosine acts as a neurodilator and vasodilator.

Reference standards of Adenosine API, and its pharmacopeial, and non pharmacopeial impurities are listed below.

73-24-5             Adenosine Ep Impurity A 73-24-5            
58-63-9             Adenosine - Impurity G            
118-00-3             Adenosine - Impurity H            
3868-33-5             8-Amino Adenosine            
 14365-45-8             2'-Deoxy-β-L-adenosine            
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    The AG dinucleotide at the 3′ splice sites of metazoan nuclear pre-mRNAs plays a critical role in catalytic step II of the splicing reaction. Previous studies have shown that replacement of the guanine by adenine in the AG (AG → GG) inhibit

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Adenine

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