Capecitabine Intermediate 1
Aug 16,2023
5-Fluorocytosine also called Capecitabine Intermediate 1 is an orally active antifungal agent with a very narrow spectrum of activity. It is indicated only for the treatment of serious systemic infections caused by susceptible strains of Candida and Cryptococcus spp.
The mechanism of action of 5-fluorocytosine (5-FC)has been studied in detail. The drug enters the fungal cell by active transport onATPases that normally transport pyrimidines. Once insidethe cell, 5-fluorocytosine is deaminated in a reaction catalyzedby cytosine deaminase to yield 5-fluorouracil(5-FU). 5-Fluorouracil is the active metabolite of the drug.
Capecitabine is an oral prodrug of 5-fluorouracil (5-FU), which is widely used for adjuvant and neoadjuvant chemotherapy of different solid tumors, particularly breast and colorectal cancers.
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