Tetrakis(triphenylphosphine)palladium: uses and Hazard

Introduction

The CAS of Tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4) is 14221-01-3 and exhibits a beautiful golden-yellow color. Low-quality or decomposed material, however, often shows a dark orange-brown color or, in extreme cases of decay, a dark greenish color. In addition, it is slightly soluble in Chloroform, ethyl Acetate, and methanol.

Uses

Tetrakis(triphenylphosphine)palladium(0), or Pd(PPh3)4, is perhaps the best-known catalyst for classical cross-coupling reactions. It is a workhorse of Pd(0)-catalyzed transformations and stands as the prototype upon which a diverse collection of palladium catalysts has been built.

Tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4) is a commonly used palladium(0) complex in chemical synthesis. It plays a vital role as a catalyst in various organic reactions, especially C-C, C-N, C-O, and C-heteroatom cross-coupling reactions. Pd(PPh3)4 finds extensive application in carbon-carbon bond-forming reactions such as the famous Heck, Suzuki-Miyaura, and Stille reactions. These reactions involve the coupling of aryl, alkyl, or vinyl halides with other organic compounds to yield valuable products. The catalytic cycle involves the oxidative addition of the organic halide to palladium(0), transmetalation with a suitable organometallic reagent or boronic acid, and reductive elimination to form the desired product. Pd(PPh3)4 has also been utilized in other transformations, including allylic substitutions, nucleophilic additions to alkenes and alkynes, and cycloadditions.

Hazard

H302 Harmful if swallowed

Acute toxicity estimate Oral - 500.1 mg/k

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink, or smoke when using this product.

P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.