Chemical Safety Data Sheet MSDS / SDS

Aniline

Revision Date:2024-04-20Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Aniline
CBnumber: CB7169544
CAS: 62-53-3
EINECS Number: 200-539-3
Synonyms: aniline,benzenamine

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash hands thoroughly after handling.

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P271 Use only outdoors or in a well-ventilated area.

P272 Contaminated work clothing should not be allowed out of the workplace.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 Wear respiratory protection.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311 IF exposed: call a POISON CENTER or doctor/physician.

P370+P378 In case of fire: Use … for extinction.

P391 Collect spillage. Hazardous to the aquatic environment

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Hazard statements

H225 Highly Flammable liquid and vapour

H227 Combustible liquid

H301 Toxic if swalloed

H311 Toxic in contact with skin

H317 May cause an allergic skin reaction

H318 Causes serious eye damage

H330 Fatal if inhaled

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H351 Suspected of causing cancer

H370 Causes damage to organs

H372 Causes damage to organs through prolonged or repeated exposure

H373 May cause damage to organs through prolonged or repeated exposure

H400 Very toxic to aquatic life

H410 Very toxic to aquatic life with long lasting effects

H412 Harmful to aquatic life with long lasting effects

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/aniline

SECTION 3: Composition/information on ingredients

Substance

Product name: Aniline
Synonyms: aniline,benzenamine
CAS: 62-53-3
EC number: 200-539-3
MF: C6H7N
MW: 93.13

SECTION 4: First aid measures

Description of first aid measures

General advice

First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	2	Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only

to qualified or authorized persons.

Handle under inert gas. Protect from moisture. Light sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject? (KCL 898)

Splash contact Material: Latex gloves

Minimum layer thickness: 0,6 mm Break through time: 60 min

Material tested:Lapren? (KCL 706 / Aldrich Z677558, Size M)

Body Protection

protective clothing

Respiratory protection

Recommended Filter type: Filter A-(P3)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

Exposure limits

TLV-TWA skin 2 ppm (～8 mg/m³) (ACGIH), 5 ppm (～19 mg/m³) (MSHA, OSHA, and NIOSH); IDLH 100 ppm (NIOSH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearance liquid
OdourNo data available
Odour Threshold2,44 ppm
pH8,8 at 36 g/l at 20 °C
Melting point/freezing pointMelting point/range: -6 °C - lit.
Initial boiling point and boiling range 184 °C - lit.
Flash point70 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits Upper explosion limit: 23 %(V) Lower explosion limit: 1,3 %(V)
Vapour pressure 0,49 hPa at 20 °C
Vapour density 3,22 - (Air = 1.0)
Relative density1.021
Water solubilitysoluble
Partition coefficient: n-octanol/waterlog Pow: 0,91 - Bioaccumulation is not expected.
Autoignition temperatureNo data available
Decomposition temperature 190 °C -
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 4,4 mPa.s at 20 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant1.91 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)

Other safety information

Surface tension 42,12 mN/m at 25 °C

Relative vapor density

3,22 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Risk of explosion with:

Oxidizing agents peroxi compounds perchlorates perchloric acid Nitric acid

Oxygen

organic nitro compounds benzene/benzene derivatives nitrates

Exothermic reaction with:

semimetallic halides Acetic anhydride acids

Risk of ignition or formation of inflammable gases or vapours with: Fluorine

Alkaline earth metals Alkali metals

Conditions to avoid

Avoid moisture. Strong heating.

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 250 mg/kg Remarks: (RTECS)
LC50 Inhalation - Rat - 4 h - 3,3 mg/l Remarks: (Lit.)
(Regulation (EC) No 1272/2008, Annex VI) LD50 Dermal - Rabbit - 840 mg/kg Remarks: (Lit.)

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation Remarks: (Lit.)

Serious eye damage/eye irritation

Causes serious eye damage. Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Respiratory or skin sensitization

May cause allergic skin reaction. Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Germ cell mutagenicity

Suspected of causing genetic defects. Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: positive
Test Type: Chromosome aberration test in vitro Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: positive
Test Type: unscheduled DNA synthesis assay Test system: rat hepatocytes
Metabolic activation: without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test Species: Rat
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 474 Result: positive
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Intraperitoneal Method: OECD Test Guideline 475 Result: positive
Test Type: Chromosome aberration test Species: Rat
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 475 Result: positive
Test Type: dominant lethal test Species: Rat
Application Route: Intraperitoneal Method: OECD Test Guideline 478 Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

Causes damage to organs through prolonged or repeated exposure. - Blood
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Aspiration hazard

No data available

Toxicity

LD50 orally in rats: 0.44 g/kg (Jacobson)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Oncorhynchus mykiss (rainbow trout) - 10,6 mg/l - 96,0 h

Remarks: (ECHA)

Toxicity to daphnia and other aquatic invertebrates

semi-static test EC50 - Daphnia magna (Water flea) - 0,16 mg/l - 48 h

(US-EPA)

Toxicity to algae

static test ErC50 - Chlorella pyrenoidosa - 175 mg/l - 72 h (OECD Test Guideline 201)

Toxicity to bacteria

EC50 - activated sludge - 2.500 mg/l - 10 min

Remarks: (Lit.)

Persistence and degradability

Biodegradability aerobic - Exposure time 30 d

Result: ca.90 % - Readily biodegradable. (OECD Test Guideline 301D)

Bioaccumulative potential

Bioaccumulation Danio rerio (zebra fish) - < 0,1 mg/l(Aniline)

Bioconcentration factor (BCF): 2,6

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Incompatibilities

May form explosive mixture with air. Fires and explosions may result from contact with halogens, strong acids; oxidizers, strong base organic anhydrides; acetic anhydride, isocyanates, aldehydes, sodium peroxide. Strong reaction with toluene diisocyanate.

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration with provision for nitrogen oxides removal from flue gases by scrubber, catalytic or thermal device.

SECTION 14: Transport information

UN number

ADR/RID: 1547 IMDG: 1547

UN proper shipping name

ADR/RID: ANILINE IMDG: ANILINE IATA: Aniline

Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

In case of blue lips, fingernails or skin treatment with 100% oxygen may be needed; the appropriate means with instructions must be available.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Specific treatment with antidotes like methylene blue can not be used for pregnant women and persons with a G6PD enzyme deficiency. These people should avoid all contact.The odour warning when the exposure limit value is exceeded is insufficient.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.