2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
![2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine price.](/CAS/GIF/500579-04-4.gif)
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- $9 - $1802
- Product name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
- CAS: 500579-04-4
- MF: C27H35N5
- MW: 429.6
- EINECS:
- MDL Number:MFCD14635408
- Synonyms:2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine;GANT 61;Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-;2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61;GNT61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476
42 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50
- 2mg
- 1mg
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3561-M001
- Product descriptionGANT61 ≥98%
- Packaging1mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2423AH
- Product descriptionGANT61
- Packaging10mg
- Price$164
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging1mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging5mg
- Price$19
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging10mg
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging50mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging100mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging250mg
- Price$172
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA109328
- Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
- Packaging1g
- Price$437
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1615
- Product descriptionGANT61
- Packaging25mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2642
- Product descriptionGANT61-NSC136476 99%
- Packaging50mg
- Price$462
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181000
- Product descriptionGANT61(NSC 136476) >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181000
- Product descriptionGANT61(NSC 136476) >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181000
- Product descriptionGANT61(NSC 136476) >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137676
- Product descriptionGANT 61
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137676
- Product descriptionGANT 61
- Packaging50mg
- Price$297.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3561-M001 | GANT61 ≥98% | 1mg | $40 | 2021-12-16 | Buy |
| AK Scientific | 2423AH | GANT61 | 10mg | $164 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 1mg | $9 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 5mg | $19 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 10mg | $28 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 50mg | $68 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 100mg | $101 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 250mg | $172 | 2021-12-16 | Buy |
| Ambeed | A109328 | 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% | 1g | $437 | 2021-12-16 | Buy |
| ApexBio Technology | A1615 | GANT61 | 25mg | $150 | 2021-12-16 | Buy |
| Axon Medchem | Axon2642 | GANT61-NSC136476 99% | 50mg | $462 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181000 | GANT61(NSC 136476) >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181000 | GANT61(NSC 136476) >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181000 | GANT61(NSC 136476) >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137676 | GANT 61 | 10mg | $85 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137676 | GANT 61 | 50mg | $297.5 | 2021-12-16 | Buy |
Properties
Melting point :110 - 113°C
Boiling point :549.0±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >2mg/mL
pka :5.97±0.10(Predicted)
form :powder
color :white to off-white
Boiling point :549.0±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >2mg/mL
pka :5.97±0.10(Predicted)
form :powder
color :white to off-white
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 61 is a GLI antagonist, inhibiting GLI1 activation of gene expression with an IC50 value of 5 μM. It does not affect signaling through NF-κB, glucocorticoid receptor, MAPK, HGF, C/EBPα, or HIF-1, supporting specificity for the Hedgehog pathway. GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated GLI1 levels, and prevent the development of 22Rv1 tumors in mice.More related product prices
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Suppliers and manufacturers
career henan chemical co
![2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine](https://img.chemicalbook.com/ProductImageEN/2019-12/small/10552f29-11d0-4cba-bcfe-100e1b47e480.jpg)
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
BOC Sciences
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
$1.00 /100ASSAYS
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine CAS:500579-04-4
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine CAS:500579-04-4