NVP-BEP800
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- $44 - $3384.15
- Product name: NVP-BEP800
- CAS: 847559-80-2
- MF: C21H23Cl2N5O2S
- MW: 480.41
- EINECS:-0
- MDL Number:MFCD18251568
- Synonyms:NVP-BEP800;2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide;VER82576;VER-82576;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800;NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 500μg
- 1MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200MG
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7557
- Product descriptionNVP-BEP800
- Packaging10mg
- Price$411
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004937
- Product descriptionNVP-BEP800 95.00%
- Packaging1MG
- Price$182.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004937
- Product descriptionNVP-BEP800 95.00%
- Packaging10MG
- Price$1006.58
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004937
- Product descriptionNVP-BEP800 95.00%
- Packaging200MG
- Price$3384.15
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4064
- Product descriptionNVP-BEP800
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4064
- Product descriptionNVP-BEP800
- Packaging10mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4064
- Product descriptionNVP-BEP800
- Packaging25mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4064
- Product descriptionNVP-BEP800
- Packaging100mg
- Price$960
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180788
- Product descriptionNVP-BEP800 >99%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180788
- Product descriptionNVP-BEP800 >99%
- Packaging250mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180788
- Product descriptionNVP-BEP800 >99%
- Packaging1g
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18383
- Product descriptionNVP-BEP800 ≥98%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18383
- Product descriptionNVP-BEP800 ≥98%
- Packaging1mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18383
- Product descriptionNVP-BEP800 ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18383
- Product descriptionNVP-BEP800 ≥98%
- Packaging10mg
- Price$281
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM151593
- Product description2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 98%
- Packaging100mg
- Price$774
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7557 | NVP-BEP800 | 10mg | $411 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004937 | NVP-BEP800 95.00% | 1MG | $182.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004937 | NVP-BEP800 95.00% | 10MG | $1006.58 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004937 | NVP-BEP800 95.00% | 200MG | $3384.15 | 2021-12-16 | Buy |
| ApexBio Technology | A4064 | NVP-BEP800 | 5mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A4064 | NVP-BEP800 | 10mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A4064 | NVP-BEP800 | 25mg | $410 | 2021-12-16 | Buy |
| ApexBio Technology | A4064 | NVP-BEP800 | 100mg | $960 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180788 | NVP-BEP800 >99% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180788 | NVP-BEP800 >99% | 250mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180788 | NVP-BEP800 >99% | 1g | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 18383 | NVP-BEP800 ≥98% | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18383 | NVP-BEP800 ≥98% | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 18383 | NVP-BEP800 ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18383 | NVP-BEP800 ≥98% | 10mg | $281 | 2024-03-01 | Buy |
| Chemenu | CM151593 | 2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 98% | 100mg | $774 | 2021-12-16 | Buy |
Properties
Density :1.396
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form :Powder
pka :13.25±0.46(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form :Powder
pka :13.25±0.46(Predicted)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Heat shock protein 90 (Hsp90) isoforms are molecular chaperones that modulate intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin , have shown promise as anti-tumor agents. NVP-BEP800 is a potent inhibitor of Hsp90β (IC50 = 58 nM) that is 70-fold less effective against two related Hsps, Grp94 (Hsp90B1) and Trap-1 (Hsp75). It is without effect (IC50 > 10 μM) against a panel of twenty kinases. NVP-BEP800 causes p23/Hsp90 dissociation and client protein degradation, which leads to growth inhibition (GI50s from 53 to 190 nM) or induction of cell death in cancer cell lines. It is orally available and has antitumor effects in human tumor xenografts in mice. Hsp90 inhibitors, including NVP-BEP800, increase the sensitivity of tumor cells to ionizing radiation. They also direct the proteasomal degradation of viral Hsp90 client proteins, including those required for latency and infectivity of Kaposi sarcoma-associated herpes virus.Related product price
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