1,1-Cyclohexanediacetic acid mono amide synthesis
- Product Name:1,1-Cyclohexanediacetic acid mono amide
- CAS Number:99189-60-3
- Molecular formula:C10H17NO3
- Molecular Weight:199.25
1130-32-1
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$24.00/5g
99189-60-3
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$20.00/1g
Yield:99189-60-3 93%
Reaction Conditions:
with water;sodium hydroxide at 50; for 6 h;Reagent/catalyst;
Steps:
1.4-1.6
(4) The lactimide (181g) was added to the lye prepared by water (500g) and sodium hydroxide (60g), the temperature was slowly raised to 50°C, and the temperature was kept and stirred for 6 hours to obtain reactant C;(5) Cool reactant C to 10°C, slowly add 36% concentrated hydrochloric acid (150g) dropwise, adjust the pH to 1-2, stir for 2h, cool to 5°C, precipitate solids, filter with suction, and wash the filter cake with cold water. Obtain the crude cyclohexyl diacetic acid monoamide;(6) Recrystallize the obtained crude product with ethyl acetate and water to obtain 185 g of pure product, with a yield of 93% and a purity of 99.5%.As shown in Figure 3-4, the1HNMR and13CNMR spectraof the product cyclohexyldiacetic acid monoamide.After analysis, it can be seen that the detection result is consistent with the structure of cyclohexyl diacetic acid monoamide, that is, the method of the present invention prepares the target product cyclohexyl diacetic acid monoamide.
References:
CN112592289, 2021, A Location in patent:Paragraph 0076; 0082-0085; 0086-0091-0093; 0094; 0099-0101
1010-26-0
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99189-60-3
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4355-11-7
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99189-60-3
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