1-(3-ACETYLPHENYL)-3-PHENYLUREA synthesis

Yield:42865-77-0 64%

Reaction Conditions:

in propan-2-one at 20; for 8 h;Inert atmosphere;

Steps:

2.1. General Procedure for the Preparation of Ureas (I- VI)

General procedure: A mixture of the corresponding 10 mmol 4/3-aminoacetophenone and 10 mmol corresponding phenyl isocyanate, benzyl isocyanate or phenethyl isocyanate were dissolved in recently prepared dry acetone (50 mL). The mixture was stirred at room temperature under a nitrogen atmosphere for eight hours. After the reaction was completed, the acetone was evaporated under vacuum. The resulting solid was crystallised with ethanol [43].

References:

Akdeniz, Güne? Y.;Akgün, Hülya;?zakp?nar, ?zlem B.;Durac?k, Merve;?ztürk, Mehmet;??can, Evin;Ba?o?lu, Faika [Letters in drug design and discovery,2022,vol. 19,# 6,p. 500 - 519]